(2R,6R)-Hydroxynorketamine hydrochloride is primarily investigated for its potential therapeutic applications in the field of mental health, particularly in the treatment of depression. It is an active metabolite of ketamine and has shown promise in producing rapid antidepressant effects, often within hours of administration, which is significantly faster than traditional antidepressants. This compound is being studied for its ability to modulate glutamate signaling in the brain, which is thought to play a key role in mood regulation. Additionally, it may have a lower risk of dissociative side effects compared to ketamine, making it a potentially safer alternative for long-term treatment. Research is ongoing to explore its efficacy, safety, and mechanisms of action in clinical settings.