Norfluoxetine hydrochloride is primarily used in the field of neuroscience and pharmacology research as a metabolite of fluoxetine, a well-known antidepressant. It serves as a valuable tool in studying the pharmacokinetics and metabolism of fluoxetine, helping researchers understand how the drug is processed in the body. Additionally, it is utilized in investigating the mechanisms of action of selective serotonin reuptake inhibitors (SSRIs), as it retains some of the pharmacological activity of its parent compound. This makes it useful for exploring the effects of SSRIs on serotonin levels and their role in treating mood disorders. In experimental settings, it is also employed to assess potential drug interactions and side effects associated with fluoxetine therapy.