Netupitant N-oxide is a primary metabolite of netupitant, a neurokinin-1 (NK1) receptor antagonist used in the prevention of chemotherapy-induced nausea and vomiting (CINV). As a metabolite, it plays a crucial role in pharmacokinetic and pharmacodynamic studies, helping to evaluate the metabolism, efficacy, and safety of netupitant, particularly in combination therapies with agents like palonosetron. This compound is utilized as a reference standard in analytical chemistry and pharmaceutical research to assess drug levels and metabolic pathways, supporting the development of improved antiemetic treatments and enhancing patient outcomes in oncology.