Used as a key building block in medicinal chemistry, particularly in the development of novel pharmaceuticals. Its unique strained bicyclic structure enables efficient bioisosteric replacement of phenyl or tert-butyl groups, improving metabolic stability and solubility. The iodo and trifluoromethyl groups allow for further functionalization via cross-coupling reactions and enhance lipophilicity, making it valuable in drug design for CNS targets and other therapeutic areas. Widely applied in fragment-based drug discovery due to its three-dimensional architecture and favorable physicochemical properties.