Used in research settings to study the modulation of the RORγt nuclear receptor, GSK6853 serves as a potent and selective inhibitor that helps regulate Th17 cell differentiation and associated cytokine production. It is primarily employed in immunological studies focusing on autoimmune diseases such as psoriasis, multiple sclerosis, and inflammatory bowel disease. By suppressing RORγt activity, GSK6853 aids in evaluating the therapeutic potential of targeting this pathway. Its high selectivity makes it a valuable tool compound for validating RORγt as a drug target and for assessing on-target effects in preclinical models.