Widely used in drug delivery systems due to its temperature and pH-responsive behavior. The polymer undergoes a phase transition near body temperature, allowing controlled release of therapeutic agents. In acidic environments, the methacrylic acid groups remain protonated, limiting swelling, while in neutral or slightly basic conditions, deprotonation increases hydrophilicity and swelling, enhancing drug release. This dual sensitivity makes it suitable for targeted delivery in tissues with specific pH and temperature profiles, such as tumor sites. Also employed in tissue engineering and smart hydrogels, where reversible swelling enables dynamic cell culture scaffolds. Used in biosensors and actuators for its rapid response to environmental changes.