Fmoc-Val-D-Cit-PAB
98%
Reagent
Code: #186618
CAS Number
1350456-67-5
blur_circular Chemical Specifications
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Molecular Information
Weight
601.69 g/mol
Formula
C₃₃H₃₉N₅O₆
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Storage & Handling
Storage
-20°C
description Product Description
Used in the synthesis of antibody-drug conjugates (ADCs) as a linker-payload component. The Fmoc-Val-D-Cit-PAB structure incorporates a self-immolative spacer (PAB) that enables controlled release of cytotoxic agents upon specific biological triggers, such as enzymatic cleavage. The D-Cit (diaminopropionic acid derivative) enhances stability and solubility during conjugation processes, while the Fmoc group allows for solid-phase peptide synthesis compatibility. This compound is particularly valuable in developing targeted cancer therapies where precise drug activation is critical.
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