Fmoc-Val-D-Cit-PAB

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Reagent Code: #186618
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CAS Number 1350456-67-5

science Other reagents with same CAS 1350456-67-5

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Weight 601.69 g/mol
Formula C₃₃H₃₉N₅O₆
inventory_2 Storage & Handling
Storage -20°C

description Product Description

Used in the synthesis of antibody-drug conjugates (ADCs) as a linker-payload component. The Fmoc-Val-D-Cit-PAB structure incorporates a self-immolative spacer (PAB) that enables controlled release of cytotoxic agents upon specific biological triggers, such as enzymatic cleavage. The D-Cit (diaminopropionic acid derivative) enhances stability and solubility during conjugation processes, while the Fmoc group allows for solid-phase peptide synthesis compatibility. This compound is particularly valuable in developing targeted cancer therapies where precise drug activation is critical.

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Size Availability Unit Price Quantity
inventory 50mg
10-20 days ฿49,340.00

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Fmoc-Val-D-Cit-PAB
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Used in the synthesis of antibody-drug conjugates (ADCs) as a linker-payload component. The Fmoc-Val-D-Cit-PAB structure incorporates a self-immolative spacer (PAB) that enables controlled release of cytotoxic agents upon specific biological triggers, such as enzymatic cleavage. The D-Cit (diaminopropionic acid derivative) enhances stability and solubility during conjugation processes, while the Fmoc group allows for solid-phase peptide synthesis compatibility. This compound is particularly valuable in developing targeted cancer therapies where precise drug activation is critical.
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