NGB 2904 hydrochloride is primarily used in research settings to study its potential as a dopamine D3 receptor antagonist. Its application is focused on understanding its effects on addiction-related behaviors, particularly in substance abuse disorders. Researchers investigate its ability to modulate dopamine signaling, which is crucial in reward pathways associated with addiction. This compound is also explored for its potential therapeutic effects in reducing drug-seeking behaviors and cravings, particularly in cases of cocaine addiction. Additionally, it is studied for its role in neuropsychiatric conditions where dopamine dysregulation plays a key role. Its specificity for the D3 receptor makes it a valuable tool in pharmacological studies aimed at developing targeted treatments for addiction and related disorders.