PJ34 HCl is primarily utilized in research settings to study the role of PARP (Poly ADP-Ribose Polymerase) enzymes in cellular processes. It is a potent PARP inhibitor, making it valuable for investigating DNA repair mechanisms, particularly in the context of cancer research. By inhibiting PARP activity, it helps scientists understand how cells respond to DNA damage and explore potential therapeutic strategies for cancers with defective DNA repair pathways, such as BRCA-mutated cancers. Additionally, PJ34 HCl is used in studies related to neuroprotection, as PARP inhibition has shown potential in reducing neuronal damage in conditions like stroke and neurodegenerative diseases. Its applications extend to exploring inflammation and oxidative stress, where PARP plays a significant role.