KU-55933 is primarily used in research to study the role of ATM kinase in cellular processes. It is a potent inhibitor of ATM kinase, which plays a critical role in DNA damage response. Researchers utilize KU-55933 to investigate how inhibiting ATM kinase affects cell cycle regulation, DNA repair mechanisms, and apoptosis. This compound is valuable in understanding the pathways involved in cancer development, as ATM kinase is often implicated in tumor suppression. Additionally, KU-55933 is employed in studies exploring the sensitivity of cancer cells to radiation and chemotherapy, providing insights into potential therapeutic strategies. Its application extends to neurodegenerative disease research, where ATM kinase dysfunction is linked to conditions like ataxia-telangiectasia. By blocking ATM kinase activity, KU-55933 helps elucidate its role in neuronal health and disease progression.