PARP-2-IN-1 is primarily used in research settings to study the role of PARP-2 in various biological processes. It serves as a selective inhibitor of PARP-2, making it a valuable tool for investigating the enzyme's function in DNA repair mechanisms, particularly in the context of cancer biology. Researchers utilize this compound to explore its potential in enhancing the efficacy of chemotherapy and radiotherapy by inhibiting DNA repair in cancer cells, thereby promoting cell death. Additionally, PARP-2-IN-1 is employed in studies aimed at understanding its effects on inflammatory diseases and neurodegenerative conditions, where PARP-2 activity is implicated. Its specificity allows for targeted experiments to dissect the distinct roles of PARP-2 compared to other PARP family members.