Used as a protected form of thiol-containing alcohols in organic synthesis, particularly in peptide and nucleotide chemistry. The THP (tetrahydropyranyl) group acts as a protecting group for the alcohol, while the disulfide (SS) linkage allows for reversible thiol protection. This dual protection enables selective deprotection under mild acidic conditions, making it valuable in stepwise synthesis where functional group compatibility is critical. Commonly applied in the preparation of bioconjugates, prodrugs, and functionalized polymers where controlled release of thiols is required. Also utilized in surface modification techniques, such as immobilizing biomolecules on gold surfaces via disulfide exchange.