Trans-2,2-dimethylcyclobutane-1,3-dicarboxylic acid is primarily used in organic synthesis as a building block for more complex chemical structures. Its rigid cyclobutane ring and carboxylic acid groups make it a valuable intermediate in the development of pharmaceuticals, where it can contribute to the creation of compounds with specific biological activities. Additionally, it is utilized in the production of specialty polymers and resins, where its unique structure can enhance the material properties such as thermal stability and mechanical strength. In research, it serves as a model compound for studying ring strain and its effects on chemical reactivity, aiding in the understanding of cyclobutane derivatives in various chemical processes.