ML-346 is primarily utilized in research settings to study and modulate the activity of the enzyme diacylglycerol kinase (DGK). It acts as an inhibitor, specifically targeting DGKα, which plays a role in cellular signaling pathways. By inhibiting DGKα, ML-346 helps researchers investigate the enzyme's function in processes such as T-cell activation, immune responses, and cancer progression. Its application is particularly valuable in understanding the molecular mechanisms underlying these biological processes, potentially aiding in the development of therapeutic strategies for immune-related disorders and cancer.