Used primarily as a derivatization reagent in analytical chemistry, especially in gas chromatography-mass spectrometry (GC-MS). It introduces a trifluoroacetyl group to compounds containing active hydrogens, such as amines, alcohols, and amides, improving their volatility and thermal stability for better detection. Commonly applied in the analysis of pharmaceuticals, steroids, and forensic samples. Also serves as a reagent in organic synthesis for protection or modification of functional groups, particularly where fluorinated analogs are desired. Its use enhances sensitivity and resolution in detection due to the strong electron-withdrawing nature of the trifluoroacetyl group.