Used as a derivatization reagent in analytical chemistry, particularly in gas chromatography and mass spectrometry. It enhances the detection of carbonyl compounds by converting them into stable derivatives with improved volatility and detectability. Its pentafluorinated structure provides strong electron-withdrawing properties, making it especially useful in electron capture detection due to high sensitivity. Also employed in the synthesis of fluorinated organic compounds where its unique electronic and steric profile influences reaction pathways and product stability.