Used as a derivatization agent in analytical chemistry, particularly in gas chromatography-mass spectrometry (GC-MS) for the analysis of compounds like alcohols, phenols, and amines. Enhances the detection and separation of these compounds by converting them into more volatile and thermally stable derivatives. Also employed in organic synthesis as a reagent for introducing trifluoromethanesulfonyl (triflyl) groups, which can improve the biological activity and stability of pharmaceutical compounds. Its strong electron-withdrawing properties make it valuable in the development of advanced materials and catalysts.