Trimethylsilyl propionate is primarily used as a derivatization agent in analytical chemistry, particularly in gas chromatography-mass spectrometry (GC-MS). It aids in the analysis of compounds by converting polar functional groups, such as hydroxyl or carboxyl groups, into less polar, more volatile trimethylsilyl derivatives. This enhances the detection and separation of these compounds during analysis. Additionally, it finds application in organic synthesis as a protecting group for alcohols and carboxylic acids, ensuring selective reactions in complex chemical processes. Its use in the production of silicone-based polymers and coatings also contributes to improved material properties, such as water repellency and thermal stability.