PAMAM dendrimers with an ethylenediamine core, particularly generation 0.0, are widely used in drug delivery systems due to their well-defined structure and ability to encapsulate or conjugate therapeutic agents. Their dendritic architecture allows for efficient transport of drugs, enhancing solubility and targeting specific cells or tissues.

In gene therapy, these dendrimers serve as non-viral vectors for delivering genetic material, such as DNA or RNA, into cells. Their positive surface charge facilitates interaction with negatively charged nucleic acids, forming stable complexes that can penetrate cell membranes.

Additionally, they are employed in diagnostic imaging as contrast agents. By modifying their surface with imaging moieties, they can improve the detection of diseases at an early stage.

In material science, these dendrimers are utilized to create nanocomposites with enhanced mechanical and thermal properties. Their ability to form precise, nanoscale structures makes them valuable in developing advanced materials for coatings, sensors, and catalysts.

Overall, their versatility and functionality make them a crucial component in various biomedical and industrial applications.