PAMAM dendrimers with an ethylenediamine core are widely used in drug delivery systems due to their unique structure and ability to encapsulate or conjugate therapeutic agents. Their highly branched, nanoscale architecture allows for precise control over drug release, enhancing bioavailability and targeting specific tissues or cells.

In gene therapy, these dendrimers serve as non-viral vectors for delivering nucleic acids, such as DNA or RNA, into cells. Their cationic surface facilitates complexation with negatively charged genetic material, improving transfection efficiency while minimizing toxicity.

Additionally, they are employed in diagnostic imaging as contrast agents. By attaching imaging moieties to their surface, they enhance the resolution and specificity of techniques like MRI or fluorescence imaging.

In material science, PAMAM dendrimers are used to modify surfaces, improve coatings, and create nanocomposites with enhanced mechanical or thermal properties. Their versatility and functionality make them valuable across biomedical, pharmaceutical, and industrial applications.