PAMAM dendrimers with an ethylenediamine core are widely used in drug delivery systems due to their unique tree-like structure, which allows for precise control over size and surface functionality. They can encapsulate or conjugate therapeutic agents, enhancing solubility, stability, and targeted delivery to specific cells or tissues. In gene therapy, these dendrimers act as non-viral vectors, efficiently binding and delivering nucleic acids like DNA or RNA into cells. Additionally, they are employed in diagnostic imaging as contrast agents, improving the resolution and specificity of imaging techniques. Their surface groups can be modified for specific applications, such as attaching targeting ligands for cancer therapy or antimicrobial agents for infection control. In materials science, they are used to create nanocomposites with enhanced mechanical, thermal, or electrical properties. Their versatility and tunability make them valuable in biomedical, industrial, and research applications.