Guanidine Hydroiodide is primarily used in organic synthesis as a strong denaturing agent for proteins. It is particularly effective in breaking hydrogen bonds, making it valuable in the study of protein folding and denaturation processes. Additionally, it serves as a reagent in the preparation of various organic compounds, including pharmaceuticals and agrochemicals. Its ability to act as a strong base and nucleophile also makes it useful in certain chemical reactions, such as the synthesis of heterocycles and other complex molecules. In biochemistry, it is employed to solubilize proteins and nucleic acids, aiding in their extraction and purification. Furthermore, it is utilized in the production of semiconductors and certain electronic materials, such as perovskite solar cells, where it enhances performance and stability.