Used as an antidote for ethylene glycol and methanol poisoning, 4-Methylpyrazole works by inhibiting alcohol dehydrogenase, the enzyme responsible for metabolizing these toxic alcohols into more harmful substances like glycolic acid, oxalic acid, or formic acid. By blocking this metabolic pathway, it prevents the formation of toxic metabolites that can cause severe metabolic acidosis, kidney damage, visual disturbances, and central nervous system depression. It is administered in clinical settings to treat patients who have ingested antifreeze or windshield washer fluids containing methanol or ethylene glycol, especially when ethanol therapy is not suitable or when rapid intervention is needed. Its use allows for more predictable pharmacokinetics and fewer side effects compared to ethanol, making it a preferred antidote in acute toxicology.