5-Ethynyluracil
≥97%(HPLC)(T)
Reagent
Code: #183087
CAS Number
59989-18-3
blur_circular Chemical Specifications
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Molecular Information
Weight
136.11 g/mol
Formula
C₆H₄N₂O₂
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Registry Numbers
MDL Number
MFCD00871973
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Physical Properties
Melting Point
320°C(dec.)(lit.)
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Storage & Handling
Storage
Room temperature, dry
description Product Description
Used as a biochemical tool in research to inhibit dihydropyrimidine dehydrogenase (DPD), an enzyme involved in the metabolism of pyrimidines. By inhibiting DPD, it enhances the effectiveness and duration of certain chemotherapy drugs, particularly 5-fluorouracil (5-FU), by preventing their breakdown in the body. This allows for lower doses of 5-FU to be used while maintaining therapeutic efficacy, reducing side effects. It is primarily used in experimental and preclinical cancer studies to modulate drug response and improve treatment outcomes.
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