The Burgess Reagent, chemically known as (methoxycarbonylsulfamoyl)triethylammonium hydroxide inner salt, is a specialty chemical used primarily in organic synthesis as a mild dehydrating agent. It facilitates the conversion of secondary and tertiary alcohols to alkenes under neutral conditions, offering high selectivity and compatibility with acid- or base-sensitive substrates. This reagent is especially valuable in the synthesis of complex molecules, including natural products and pharmaceuticals. Additionally, it enables cyclodehydration reactions to form heterocycles such as oxazoles and thiazoles. It is also employed in the preparation of other unsaturated compounds and strained rings like aziridines, serving as a versatile tool in medicinal chemistry.