(S)-10-Allyl-4-ethyl-4,9-dihydroxy-1,12-dihydro-14H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H)-dione
98%
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This compound is a camptothecin derivative that inhibits topoisomerase I, exhibiting anticancer activity particularly against colorectal, lung, and ovarian cancers. The allyl group at position 10 and ethyl group at position 4 enhance its water solubility and in vivo stability, improving drug delivery efficiency and reducing toxicity to normal cells. It is under development as a potent chemotherapeutic agent, especially in targeted delivery or nanotechnology-based systems to increase tumor accumulation and minimize side effects. Used in research for its potential as an antitumor agent via DNA intercalation, replication disruption, and apoptosis induction in leukemia and solid tumor models. Limited to laboratory and preclinical studies; not approved for therapeutic use.
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