Piptocarphin F exhibits significant antiproliferative activity, making it a compound of interest in cancer research. It has shown potent cytotoxic effects against several human cancer cell lines, particularly in studies involving breast and lung cancer cells. Its mechanism appears to involve the induction of apoptosis through mitochondrial pathways and the modulation of key regulatory proteins in the cell cycle. Due to its natural origin and selective toxicity toward tumor cells, Piptocarphin F is being investigated as a potential lead compound for the development of novel chemotherapeutic agents. Additionally, it may contribute to the understanding of structure-activity relationships in bioactive lignans, supporting the design of more effective derivatives.