Picropodophyllotoxin
10mM in DMSO
Reagent
Code: #224176
CAS Number
477-47-4
science Other reagents with same CAS 477-47-4
blur_circular Chemical Specifications
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Molecular Information
Weight
414.41 g/mol
Formula
C₂₂H₂₂O₈
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Registry Numbers
MDL Number
MFCD01742647
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Storage & Handling
Storage
-20°C
description Product Description
Used in cancer research due to its ability to inhibit the insulin-like growth factor 1 receptor (IGF-1R), which plays a key role in tumor cell proliferation and survival. Shows potential as an antitumor agent, particularly in studies involving glioblastoma, melanoma, and other solid tumors. Its mechanism involves inducing cell cycle arrest and promoting apoptosis in cancer cells without significant toxicity to normal cells, making it a candidate for targeted cancer therapy development.
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