Used in topical treatments for actinic keratosis, a precancerous skin condition caused by prolonged sun exposure. The compound works by promoting cell death in abnormal skin cells and modulating immune responses in the affected area. It is valued for its ability to target damaged cells with minimal impact on surrounding healthy tissue. Its mechanism involves activation of protein kinase C, leading to rapid lesion clearance. Due to its potency, it is typically prescribed for short-duration therapy to reduce the risk of skin irritation.