Used in targeted cancer therapies, particularly in the development of antibody-drug conjugates (ADCs). Its modified structure enhances stability and specificity, allowing precise delivery of the cytotoxic agent to tumor cells while minimizing damage to healthy tissues. The trifluoroacetyl group improves lipophilicity and cellular uptake, making it effective against resistant cancer cell lines. It is also employed in research settings to study drug resistance mechanisms and intracellular drug trafficking.