Naproxen etemesil is primarily used as a prodrug of naproxen, designed to improve the therapeutic profile and reduce gastrointestinal side effects. It is commonly prescribed for the treatment of inflammatory conditions such as rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis. The compound is also effective in managing acute pain, including musculoskeletal injuries, dental pain, and dysmenorrhea. Its delayed-release formulation allows for sustained anti-inflammatory and analgesic effects, making it suitable for long-term use in chronic conditions. Additionally, it is utilized in post-surgical pain management due to its ability to provide prolonged relief with fewer dosing intervals.