Indometacin sodium is widely used in medical applications due to its potent anti-inflammatory, analgesic, and antipyretic properties. It is primarily administered to treat conditions such as rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis, helping to reduce pain, swelling, and stiffness in joints. It is also effective in managing acute gout attacks by alleviating inflammation and discomfort. In some cases, it is used to treat migraines and other types of headaches. Additionally, it is applied in postoperative settings to control pain and inflammation. The sodium salt form enhances its solubility, making it suitable for intravenous or intramuscular administration in emergency situations. However, it is used with caution due to potential side effects, particularly on the gastrointestinal tract and kidneys.