Licofelone is used as an anti-inflammatory and analgesic agent, primarily investigated for the treatment of osteoarthritis. It works by inhibiting both cyclooxygenase (COX) and 5-lipoxygenase (5-LOX) pathways, which helps reduce the production of prostaglandins and leukotrienes—key mediators of inflammation and pain. Due to its dual inhibitory action, licofelone may offer improved gastrointestinal safety compared to traditional NSAIDs, making it a potential alternative for long-term management of chronic inflammatory conditions. It has shown promise in reducing cartilage degradation and improving joint function in preclinical and clinical studies.