Licofelone is used as an anti-inflammatory and analgesic agent, primarily investigated for the treatment of osteoarthritis. It works by inhibiting both cyclooxygenase (COX) and 5-lipoxygenase (5-LOX) pathways, which helps reduce the production of prostaglandins and leukotrienes—key mediators in inflammation and pain. This dual inhibition may offer improved gastrointestinal safety compared to traditional NSAIDs, which only target COX enzymes. Due to its mechanism, licofelone has been studied for potential use in patients at risk for NSAID-related gastrointestinal complications. It has also shown chondroprotective properties in preclinical studies, suggesting it may help preserve cartilage in joint diseases. Though not widely marketed, it remains of interest for its unique pharmacological profile in managing chronic inflammatory conditions.