Trans-Cyclobutane-1,2-dicarboxylic acid is primarily used in organic synthesis and pharmaceutical research. Its rigid cyclobutane ring structure makes it a valuable building block for creating complex molecules, particularly in the development of drug candidates. It is often employed in the synthesis of chiral compounds due to its stereochemical properties, which can influence the biological activity of the resulting molecules. Additionally, it serves as a precursor in the production of specialty chemicals and polymers, where its unique geometry can impart specific mechanical or chemical properties to the final material. Researchers also explore its potential in designing new materials with tailored functionalities, such as catalysts or advanced polymers.