Cubane-1,4-diamine dihydrochloride serves as a versatile, rigid scaffold in pharmaceutical research, where the amine groups facilitate conjugation and precise spatial control of functional groups in drug design, exploiting the unique strained cubic structure of cubane for enhanced stability and bioactivity. It acts as a building block in organic synthesis for novel compounds with tailored properties. In materials science, it contributes to developing polymers with distinctive thermal and mechanical characteristics. Additionally, the primary amines enable its use in coordination chemistry to form metal-organic frameworks for applications in gas storage and catalysis. While retaining the high-energy potential of the cubane core, this derivative is primarily utilized in synthetic and biomedical contexts rather than direct energetic materials.