(2-Chloro-5-pyridyl)Methylzinc chloride is primarily used in organic synthesis as an organozinc reagent. It is particularly valuable in cross-coupling reactions, such as Negishi coupling, where it facilitates the formation of carbon-carbon bonds. This reagent is often employed in the synthesis of complex organic molecules, including pharmaceuticals and agrochemicals, due to its ability to introduce the (2-chloro-5-pyridyl)methyl group into target structures. Its reactivity and selectivity make it a useful tool in the development of novel compounds with potential biological activity. Additionally, it is utilized in the preparation of pyridine derivatives, which are important intermediates in various chemical industries.