Angelicin is primarily used in photochemotherapy, particularly in the treatment of skin conditions like psoriasis and vitiligo. It works by sensitizing the skin to ultraviolet (UV) light through DNA intercalation, forming monoadducts that inhibit cell proliferation and reduce symptoms. Additionally, angelicin is being studied for its potential in cancer treatment due to its ability to inhibit DNA replication in cancer cells when activated by UV light. It also shows promise in antiviral research, particularly against herpes simplex virus, by interfering with viral DNA synthesis. In agriculture, angelicin is investigated for its role as a natural phototoxin for controlling plant growth and as an insecticide against pests.