Difluprednate is primarily used as a potent anti-inflammatory agent in ophthalmic preparations. It is prescribed to treat inflammation and pain following ocular surgery, such as cataract extraction. Due to its strong glucocorticoid activity, it effectively reduces swelling, redness, and itching in the eye by suppressing the migration of inflammatory cells and inhibiting the release of mediators involved in the inflammatory response. It is also used off-label for managing non-infectious anterior uveitis. Its formulation allows for better corneal penetration compared to some other corticosteroids, making it effective at lower dosing frequencies. Careful monitoring is required to avoid potential side effects like increased intraocular pressure or secondary eye infections.