6α-Methylprednisolone 21-hemisuccinate sodium salt is widely used in medical and pharmaceutical applications due to its potent anti-inflammatory and immunosuppressive properties. It is commonly employed in the treatment of severe allergic reactions, autoimmune disorders, and inflammatory conditions such as rheumatoid arthritis, asthma, and lupus. The compound is often administered via injection, providing rapid relief in acute situations. Additionally, it is utilized in managing certain types of cancer and preventing organ transplant rejection. Its water-soluble nature enhances its bioavailability, making it effective for intravenous or intramuscular delivery. In research, it serves as a key reference standard for studying glucocorticoid activity and developing new therapeutic agents.