Fibrinogen plays a critical role in blood clotting and wound healing. It is converted to fibrin during injury, forming a mesh that stabilizes blood clots and prevents excessive bleeding. In clinical settings, fibrinogen is used in surgical procedures to manage bleeding, especially in cardiac, trauma, and liver surgeries where clotting factors may be depleted. It is also a key component in fibrin sealants, which are applied topically to seal tissues, adhere grafts, and control oozing blood. In patients with congenital or acquired fibrinogen deficiency, replacement therapy with fibrinogen concentrate helps restore hemostasis. Additionally, fibrinogen levels are monitored in critical care as an indicator of inflammation and coagulation status.