Used primarily as an anticoagulant, especially in patients with heparin-induced thrombocytopenia (HIT). It directly inhibits thrombin, both free and clot-bound, preventing fibrin formation and platelet activation. Commonly administered during percutaneous coronary interventions (PCI) in HIT patients to prevent clot formation. Also used in diagnostic procedures where anticoagulation is needed but heparin is contraindicated. Its short half-life allows for rapid clearance and precise dose control, making it suitable for continuous infusion in critical care settings.