ZK756326 2HCl is primarily utilized in preclinical research and pharmacological studies due to its potential as a selective antagonist. It is often investigated for its role in modulating specific receptor activity, which makes it valuable in understanding neurological and psychiatric disorders. Researchers use it to explore its effects on behavior, cognition, and neural pathways, particularly in models of anxiety, depression, or other CNS-related conditions. Its application is largely confined to laboratory settings, where it aids in the development of novel therapeutic strategies and the elucidation of receptor mechanisms.