SR 8278 is primarily utilized in research settings to study its effects on circadian rhythms and metabolic processes. It acts as a reverse agonist of the nuclear receptor REV-ERB, which plays a significant role in regulating biological clocks and metabolism. Researchers employ SR 8278 to investigate its potential in modulating sleep-wake cycles, lipid metabolism, and glucose homeostasis. Its application extends to preclinical studies aimed at understanding its therapeutic potential for disorders related to circadian misalignment, such as sleep disorders, obesity, and diabetes. Additionally, SR 8278 is used to explore its impact on inflammatory pathways and its potential role in managing inflammatory diseases. This compound serves as a valuable tool in advancing the understanding of the intricate relationship between circadian biology and metabolic health.