Octylsilane bonded silica gel is widely used in chromatography, particularly in reversed-phase high-performance liquid chromatography (HPLC). It serves as a stationary phase for separating non-polar and moderately polar compounds. Its octyl groups provide a hydrophobic surface, making it suitable for analyzing pharmaceuticals, environmental samples, and biological molecules. It is also employed in solid-phase extraction (SPE) for sample preparation, where it helps isolate and concentrate target analytes from complex matrices. Additionally, its stability and reproducibility make it a preferred choice for quality control and research applications in analytical laboratories.