Silica gel plates, particularly those used in preparative layer chromatography (PLC), are widely employed in the separation and purification of chemical compounds. These plates are essential in laboratories for isolating specific substances from complex mixtures, especially in organic synthesis and natural product extraction. They are highly effective in separating compounds based on their polarity, making them valuable in pharmaceutical research for purifying drug intermediates and active pharmaceutical ingredients (APIs). Additionally, silica gel plates are used in biochemistry for isolating and analyzing biomolecules such as amino acids, peptides, and lipids. Their high resolution and reproducibility make them a preferred choice for analytical and preparative purposes in both academic and industrial settings.