Column-layer chromatographic silica gel is widely used in the separation and purification of compounds in both analytical and preparative chemistry. It serves as a stationary phase in column chromatography, enabling the separation of complex mixtures based on differences in polarity, size, or affinity. In thin-layer chromatography (TLC), it is applied as a coating on plates to facilitate the rapid analysis of sample components. This material is particularly valuable in pharmaceutical research for isolating and identifying active ingredients, as well as in biochemistry for purifying proteins, nucleic acids, and other biomolecules. Its high surface area and tunable pore size make it effective for resolving closely related compounds, ensuring high purity and yield in various chemical and biological processes.