Monodisperse amino silica microspheres are widely used in chromatography for the separation and purification of biomolecules, such as proteins and nucleic acids, due to their uniform size and surface functionalization. They serve as excellent stationary phases in high-performance liquid chromatography (HPLC) and affinity chromatography, providing high resolution and efficiency.

In drug delivery systems, these microspheres are utilized as carriers for controlled release of therapeutic agents, owing to their biocompatibility and ability to be functionalized with targeting ligands. They are also employed in diagnostics as solid supports for immobilizing antibodies, enzymes, or DNA probes, enhancing the sensitivity and specificity of assays like ELISA and PCR.

Additionally, they play a role in catalysis, where their amino groups can anchor metal nanoparticles or organocatalysts, facilitating various chemical reactions. In environmental applications, they are used for the adsorption and removal of heavy metals or organic pollutants from water, leveraging their high surface area and functional groups for efficient binding.

Overall, their versatility and tunable properties make them valuable in diverse scientific and industrial fields.