Sodium 1-Propanesulfonate is widely used as an ion-pairing reagent in ion-pair chromatography, a technique employed for the separation and analysis of ionic and polar compounds. It is particularly effective in enhancing the retention and resolution of charged analytes, such as organic acids, bases, and biomolecules, on reversed-phase columns. By forming ion pairs with the analytes, it improves their interaction with the stationary phase, leading to better separation efficiency. This reagent is commonly applied in pharmaceutical analysis, environmental testing, and biochemical research for the quantification of complex mixtures. Its compatibility with various detection methods, including UV and mass spectrometry, makes it a versatile choice for analytical applications.