1,1,1,3,3,3-Hexafluoro-2-propanol (HFIP) is widely used as a solvent in various chemical reactions due to its unique properties. It is particularly effective in dissolving peptides and proteins, making it valuable in biochemistry and pharmaceuticals for studying protein structures and folding mechanisms. HFIP is also utilized in polymer chemistry as a solvent for fluoropolymers and in the synthesis of specialty materials. Additionally, it serves as a reagent in organic synthesis, facilitating reactions like esterifications and polymerizations. Its ability to stabilize certain intermediates makes it useful in catalysis and material science. In analytical chemistry, HFIP is employed in chromatography, including as a derivatizing agent for gas chromatography (GC) analysis and as a mobile phase modifier to improve separation efficiency in techniques like HPLC.